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Dr. Blake joined the college in 2009. His research focuses on the cellular events in pulmonary macrophages and epithelial cells that initiate immunological changes using human and mouse models. He studies numerous cell biology topics including how inhaled environmental toxins and particulates alter the antioxidant/oxidative balance in the lung to the effectiveness of sattabacin against the Varicella Zoster Virus infection in human fibroblast cells.
He advises Fort Lewis student researchers under the National Institute of General Medical Sciences-Maximizing Access to Research Careers (MARC) U-STAR program. Dr. Blake has taught an environmental health and disease course in Costa Rica through the University Studies Abroad Consortium. Prior to joining Fort Lewis, Dr. Blake was a postdoctoral fellow at Johns Hopkins University, where he researched the role of Nrf2 in Chronic Obstructive Pulmonary Disease (COPD).
Dr. Blake is the recipient of the FLC Skyhawk Award (2012 and 2016) and the Health and Environmental Sciences Institute Immunotoxicology Young Investigator Travel Award (2012).
“Synthesis and characterization of novel caffeic acid derivatives against Paenibacillus larvae.” Journal of Invertebrate Pathology. 2019.
“Synthesis and characterization of trans-dichlorotetrakis(imidazole)cobalt(III) chloride: a new cobalt(III) coordination complex with potential prodrug properties.”Bioinorganic Chemistry and Applications. 2018.
“Ablation of the CD9 receptor in Human Lung Cancer Cells using CRISPR/Cas alters Migration to Chemoattractants including IL-16.” Cytokine. 2018.
Dr. Blake presents "Understanding Vaccines - Vaccine Exemptions and Their Effect on Colorado Children," at the Powerhouse Science Center, Durango, CO, Friday June 17 at 6 p.m. During this presentation Blake addresses three major topics: 1) How immunity is produced through vaccinations, 2) What vaccination exemptions are and their effect on vaccination rates in Colorado, 3) current misconceptions of vaccinations.
"Soluble extracellular Klotho decreases sensitivity to cigarette smoke induced cell death in human lung epithelial cells," Toxicology in Vitro, 29(7), pp. 1647–1652, 2015
“Increased levels of soluble extracellular Klotho, generated by the stable overexpression in human lung epithelial cells, decreases sensitivity to cigarette smoke induced cell death,” Toxicology In Vitro, 2015
“Antiviral Activity of (+)-Sattabacin Against Varicella Zoster,” Bioorganic and Medical Chemistry Letters, 2013
“Sulforaphane inhibits de novo synthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract,” Journal of Immunotoxicology, 2011
“4-Methyl-3-nitro-benzoic acid, a migration inhibitor, prevents breast cancer metastasis in SCID mice,” Cancer Letters, 2011
“Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation,” American Journal of Respiratory and Cell and Molecular Biology, 2009
“Autoantibody Profiles of an Asbestos-Exposed Population. "Autoimmunity: Roles, Regulations and Disorders" Nova Science Publishers, Inc. Hauppauge NY, 2009
Invited Speaker for the Lifelong Learning Series, “Understanding The Science Behind Vaccines And Their Impact On One’s Personal Health”
Keynote Speaker for the Tri-Beta National Convention, “Suppressing Pulmonary Inflammation Initiated By Cigarette Smoke By Activating Nrf2, 2010
Dr. David Blake is participating as Senior Personnel in a multi-institutional NSF PREM (The Partnership for Research and Education in Materials for Functional Nanomaterials) grant that provides for the education and training of students (undergraduate and graduate) in the area of material science. Awarded September 2018, PI: Ryan Haaland.
The Society of Toxicology awarded a $500 grant to Associate Professor of Biology David Blake to support his students' undergraduate research into the effects of derivatives of caffeic acid. [7/18/18]